Bioactive Small Molecules
Selleck Chemical LLC BIX 02188 S1530-5mg
BIX02188 is a selective inhibitor of MEK5 with IC50 of 4 3 nM also inhibits ERK5 catalytic activity with IC50 of 810 nM and does not inhibit closely related kinases MEK1 MEK2 ERK2 and JNK2
Cayman Chemical ANTIBODY GS-7340 50mg
A prodrug from of tenofovir; reduces HIV-1 viral replication in MT-2 cells (EC50 = 5 nM)
Cayman Chemical ANTIBODY CyromazIn 25mg
A triazine insecticide; completely inhibits larval development of the Australian sheep blow fly (0.5 ppm in rearing medium); reduces egg production by adult blow flies and subsequent larval development (1-20 μg/ml in drinking water); reduces proliferation of the house fly in chicken manure
Selleck Chemical LLC Nordihydroguaiaretic acid (NDGA) S3984-25mg
Nordihydroguaiaretic acid (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub Larrea tridentata (Sesse and Moc ex DC) Coville (creosote bush) It is a recognized inhibitor of lipoxygenase (LOX) and has antioxidant and free radical scavenging properties Nordihydroguaiaretic acid (NDGA) is a cytotoxic insulin-like growth factor-I receptor (IGF-1R)/HER2 inhibitor and induces apoptosis
Cayman Chemical ANTIBODY CalycosIn 25mg
An isoflavone with diverse biological activities; ER partial agonist that inhibits 17β-estradiol binding to ERα and ERβ (IC50s = 83.14 and 40.38 μM, respectively); induces tube formation by HUVECs in a Matrigel™ assay and angiogenesis in zebrafish; reduces growth of the poW and Dd2 strains of P. falciparum (IC50s = 4.2 and 9.8 μg/ml, respectively); selectively toxic for T. brucei brucei over Vero cells (IC50s = 12.7 and 159 μM, respectively); scavenges DPPH free radicals in a cell-free assay; inhibits xanthine/xanthine oxidase-induced toxicity in PC12 cells (EC50 = 50 ng/ml); reduces ALT and AST activity, triglyceride accumulation, and hepatic fibrosis in a mouse model of NASH at 12.5 and 25 mg/kg; decreases infarct volume and brain edema in a rat model of focal cerebral ischemia and reperfusion injury
Cayman Chemical IperoxoIodIde 5mg
An agonist of muscarinic acetylcholine receptors; stimulates [35S]GTPγS binding CHO cell membranes expressing human M2 muscarinic receptors and cell membranes expressing M4 muscarinic receptors (EC50s = 2.12 and 8.47 nM, respectively); induces M1-dependent inhibition of twitch response in electrically-stimulated isolated rabbit vas deferens (pD2 = 9.87) and M3-mediated contraction of isolated guinea pig ileum (pD2 = 9.78); reduces formalin-induced paw licking and acetic acid-induced writhing in mice (ED50s = 0.004 and 0.001 mg/kg, respectively)
Medchemexpress LLC Fmoc-VAP-MMAE | 1912408-91-3 | 1259.57 | 100 MG
Fmoc-VAP-MMAE is an agent-linker conjugate for Antibody-Drug Conjugates (ADC). It is composed of an ADC linker, a tubulin inhibitor known as MMAE, and a protective Fmoc group.
- Agent-linker conjugate for ADC
- Composed of an ADC linker
- Includes a tubulin inhibitor (MMAE)
- Features a protective Fmoc group
Medchemexpress LLC Gilteritinib hemifumarate | 1254053-84-3 | 99.8% | 610.75 | 100 MG
Gilteritinib hemifumarate | 1254053-84-3 | 99.8% | 610.75 | 100 MG
Medchemexpress LLC Cinacalcet | 226256-56-0 | 99.9% | 357.41 | 100 MG
Cinacalcet is an orally active, allosteric agonist of the Ca receptor (CaR), primarily used for cardiovascular disease research. In in vivo studies, it has been shown to significantly reduce parathyroid gland weight in 5/6 nephrectomy animals and blood ionized calcium levels in sham animals. It also causes a marked reduction in circulating parathyroid hormone.
- Orally active Ca receptor agonist
- Reduces parathyroid gland weight in nephrectomy models
- Decreases blood ionized calcium levels
- Lowers circulating parathyroid hormone
- White to off-white solid appearance
- Stable for extended periods when stored as powder or in solvent
Medchemexpress LLC TATA Box Binding Protein Antibody (YA3260) | 100 UL
TATA Box Binding Protein (TBP) antibody (Clone NO.: YA3260) is a rabbit-derived, non-conjugated IgG monoclonal antibody designed to recognize and bind promoters with or without a TATA box, facilitating the assembly of the pre-initiation complex (PIC) in RNA polymerase II (Pol II)-dependent transcription.
- Host: Rabbit
- Reactivity: Human, mouse
- Conjugation: Non-conjugated
- Applications: WB, IHC-P, IHC-F, ICC/IF, IP
- Research field: Epigenetics and nuclear signaling
- Storage conditions: Store at -20°C for 1 year; avoid repeated freeze/thaw cycles
- Purity: Affinity purified
- Molecular weight: 38 kDa (predicted and observed)
Cayman Chemical ANTIBODY 93-O17S 250mg
An ionizable cationic lipidoid; has been used in the synthesis of lipid nanoparticles for the delivery of Cre recombinase and ribonucleoproteins for genome editing in mice; LNPs containing 93-O17S have been used for the intratumoral delivery of cGAMP to enhance cross-presentation of tumor antigens and STING activation in a B16/F10 murine melanoma model